Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 2.312


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPAchr21_+_27107522-0.523.1e-03Click!
GABPB1chr15_-_506473490.393.5e-02Click!
ELK4chr1_-_2056019990.355.9e-02Click!
ELK1chrX_-_475099930.106.0e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_80574853 10.910 NM_130897
 DYNLRB2
dynein, light chain, roadblock-type 2
chr15_+_71184781 6.158 NM_001199017
NM_017691
NM_001199018
 LRRC49


leucine rich repeat containing 49


chr1_-_67390413 5.858 NM_024763
NM_207014
 WDR78

WD repeat domain 78

chr17_+_45908992 5.470 NM_033413
 LRRC46
leucine rich repeat containing 46
chr11_-_47736896 4.856 NM_024783
 AGBL2
ATP/GTP binding protein-like 2
chr11_-_111944757 4.842 NM_001082619
NM_138789
 PIH1D2

PIH1 domain containing 2

chr11_+_61129831 4.790 TMEM138
transmembrane protein 138
chr3_-_47324255 4.463 NM_001134878
NM_022342
NM_182902
 KIF9


kinesin family member 9


chr11_+_6502607 4.389 NM_012192
 FXC1
fracture callus 1 homolog (rat)
chr21_-_33984865 4.288 NM_021254
 C21orf59
chromosome 21 open reading frame 59
chr1_+_118472364 4.197 NM_006784
 WDR3
WD repeat domain 3
chr20_+_49575347 3.956 NM_014484
 MOCS3
molybdenum cofactor synthesis 3
chr3_-_180397261 3.819 NM_181426
 CCDC39
coiled-coil domain containing 39
chr1_+_20512577 3.783 NM_152376
 UBXN10
UBX domain protein 10
chr11_+_61129407 3.779 NM_016464
 TMEM138
transmembrane protein 138
chr2_-_27603584 3.747 NM_144631
 ZNF513
zinc finger protein 513
chr2_+_219536719 3.706 NM_001243313
NM_015690
 STK36

serine/threonine kinase 36

chr2_-_99771186 3.620 NM_025244
 TSGA10
testis specific, 10
chr2_-_27603249 3.602 NM_001201459
 ZNF513
zinc finger protein 513
chrX_-_99665270 3.585 NM_001105243
NM_001184880
NM_020766
 PCDH19


protocadherin 19



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 122 entries
enrichment   p-value GO term description
2.57 1.83e-06 GO:0006353 transcription termination, DNA-dependent
2.49 3.00e-02 GO:0006369 termination of RNA polymerase II transcription
2.31 3.20e-04 GO:0006354 transcription elongation, DNA-dependent
2.29 1.54e-13 GO:0000375 RNA splicing, via transesterification reactions
2.28 8.32e-13 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.28 8.32e-13 GO:0000398 nuclear mRNA splicing, via spliceosome
2.22 3.34e-02 GO:0006368 transcription elongation from RNA polymerase II promoter
2.17 6.74e-04 GO:0006352 transcription initiation, DNA-dependent
2.17 2.05e-02 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.13 4.51e-02 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.13 4.51e-02 GO:0072594 establishment of protein localization to organelle
2.08 2.31e-14 GO:0008380 RNA splicing
2.07 2.50e-02 GO:0000216 M/G1 transition of mitotic cell cycle
2.07 2.50e-02 GO:0051443 positive regulation of ubiquitin-protein ligase activity
2.06 2.13e-08 GO:0022613 ribonucleoprotein complex biogenesis
2.06 3.76e-02 GO:0008063 Toll signaling pathway
2.05 9.62e-03 GO:0006364 rRNA processing
2.03 2.39e-08 GO:0071843 cellular component biogenesis at cellular level
2.03 3.25e-02 GO:0051351 positive regulation of ligase activity
2.03 3.25e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
2.85 1.62e-02 GO:0044452 nucleolar part
2.70 1.45e-04 GO:0015030 Cajal body
2.53 2.12e-07 GO:0071013 catalytic step 2 spliceosome
2.52 2.35e-13 GO:0005681 spliceosomal complex
2.21 1.47e-14 GO:0016604 nuclear body
2.18 6.74e-07 GO:0016607 nuclear speck
2.14 1.72e-02 GO:0000123 histone acetyltransferase complex
2.12 3.97e-02 GO:0016605 PML body
2.04 4.91e-02 GO:0000502 proteasome complex
1.97 1.44e-02 GO:0000790 nuclear chromatin
1.80 4.14e-15 GO:0030529 ribonucleoprotein complex
1.75 5.68e-13 GO:0005730 nucleolus
1.70 1.76e-16 GO:0044451 nucleoplasm part
1.60 9.63e-35 GO:0031981 nuclear lumen
1.60 1.17e-23 GO:0005654 nucleoplasm
1.56 7.04e-37 GO:0044428 nuclear part
1.52 6.14e-33 GO:0070013 intracellular organelle lumen
1.51 4.52e-33 GO:0031974 membrane-enclosed lumen
1.51 6.73e-32 GO:0043233 organelle lumen
1.51 3.20e-02 GO:0044440 endosomal part

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
2.01 8.28e-04 GO:0008026 ATP-dependent helicase activity
2.01 8.28e-04 GO:0070035 purine NTP-dependent helicase activity
1.98 4.26e-05 GO:0004386 helicase activity
1.92 1.63e-02 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
1.90 2.44e-05 GO:0008168 methyltransferase activity
1.85 9.44e-05 GO:0016741 transferase activity, transferring one-carbon groups
1.57 9.41e-13 GO:0003723 RNA binding
1.52 1.84e-02 GO:0042623 ATPase activity, coupled
1.51 2.28e-03 GO:0016887 ATPase activity
1.49 2.65e-03 GO:0003712 transcription cofactor activity
1.48 3.07e-03 GO:0000988 protein binding transcription factor activity
1.48 3.07e-03 GO:0000989 transcription factor binding transcription factor activity
1.34 2.80e-23 GO:0003676 nucleic acid binding
1.28 1.07e-09 GO:0003677 DNA binding
1.28 6.62e-08 GO:0008270 zinc ion binding
1.23 9.10e-06 GO:0046914 transition metal ion binding
1.16 3.25e-02 GO:0000166 nucleotide binding
1.14 1.61e-11 GO:0005515 protein binding
1.12 2.46e-02 GO:0043167 ion binding
1.12 2.47e-02 GO:0043169 cation binding